What is TEZSPIRE?

TEZSPIRE is a treatment that proactively reduces inflammation. TEZSPIRE can help shrink your nasal polyps and reduce congestion.

TEZSPIRE works in a unique way to help treat your nasal polyps

In response to triggers, such as viruses, allergens, and environmental pollutants, your body releases a protein called thymic stromal lymphopoietin (TSLP).

As TSLP builds up, it creates a chain reaction of inflammation that can trigger symptoms caused by nasal polyps.

TEZSPIRE is the first and only biologic that targets TSLP, a key source of inflammation, helping to stop the chain reaction that can lead to the symptoms caused by nasal polyps.

Nasal Polyps Doctor Nasal Polyps Doctor

The mechanism of action for TEZSPIRE in the treatment of nasal polyps and asthma is not fully understood.

TEZSPIRE helps shrink nasal polyps and reduce congestion

In a one-year clinical trial, TEZSPIRE was proven to help:

Improve congestion

TEZSPIRE provides congestion relief that lasts. TEZSPIRE patients experienced a 68% improvement in nasal congestion score.

On average, after 1 year, people taking TEZSPIRE had a reduction in their nasal congestion score by 1.76 vs 0.81 in people taking a placebo (difference in 0.95 points between TEZSPIRE and placebo groups. Starting score in TEZSPIRE patients was 2.59 vs 2.55 in placebo).

Shrink nasal polyps

TEZSPIRE can reduce the size of nasal polyps.

Patients experienced a 92% reduction in the need for surgery and/or steroids

In a clinical study, the proportion of patients needing nasal polyp surgery and/or systemic corticosteroids was 5.7% in the group taking TEZSPIRE and 30.6% in the group who didn’t take TEZSPIRE.

Improve your sense of smell

TEZSPIRE significantly improved loss of smell for some patients.

Individual results may vary.

TEZSPIRE can help relieve nasal polyps symptoms

The SNOT-22 Questionnaire measures the impact of nasal polyps on factors that could impact you, such as loss of sense of smell, waking up at night, and decreased productivity.

The study was not designed to measure the impact of treatment on individual categories, so improvement in the total score doesn’t necessarily reflect a positive effect on specific items.

TEZSPIRE is specifically designed to target a key source of inflammation, which can cause nasal polyps and severe asthma.

Get help for severe asthma

Prepare for your specialist appointment

Before you see your doctor, it’s helpful to consider a few questions about your nasal polyps to see if TEZSPIRE could be right for you.

See questions

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Important Safety Information

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Important Safety Information

Do not use TEZSPIRE if you are allergic to tezepelumab-ekko or any of its ingredients.

Do not use to treat sudden breathing problems.

TEZSPIRE may cause serious side effects, including:

  • allergic (hypersensitivity) reactions, including anaphylaxis. Serious allergic reactions can happen after your TEZSPIRE injection. Allergic reactions can sometimes happen hours or days after you get a dose of TEZSPIRE. Call your healthcare provider or get emergency help right away if you get any of the following symptoms of an allergic reaction:
    • rash
    • breathing problems
    • hives
    • red, itchy, swollen, or inflamed eyes
    • swelling of your face, mouth, and tongue
    • fainting, dizziness, feeling lightheaded

Before using TEZSPIRE, tell your healthcare provider about all of your medical conditions, including if you:

  • have ever had a severe allergic reaction.
  • have a parasitic (helminth) infection.
  • have recently received or are scheduled to receive any vaccinations. You should not receive a “live vaccine” if you are treated with TEZSPIRE.
  • are pregnant or plan to become pregnant.
  • are breastfeeding or plan to breastfeed. It is not known if TEZSPIRE passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you use TEZSPIRE.
  • are taking prescription and over-the-counter medicines, vitamins, or herbal supplements.

Do not change or stop taking your other asthma medicines unless instructed to do so by your healthcare provider.

The most common side effects of TEZSPIRE include: Sore throat, joint and back pain, common cold symptoms, flu, upper respiratory tract infections, injection site reactions, and nose bleeds. These are not all the possible side effects.

Approved Use

TEZSPIRE is a prescription medicine used:

  • with other asthma medicines for the maintenance treatment of severe asthma in people 12 years of age and older whose asthma is not controlled with their current asthma medicine.
  • with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyps (CRSwNP) in people 12 years of age and older whose CRSwNP is not controlled with their current CRSwNP medicine.

TEZSPIRE helps:

  • prevent severe asthma attacks (exacerbations) and can improve your breathing.
  • reduce the size of your polyps, improve symptoms including i.e. nasal congestion and loss of smell, and reduce the need for oral corticosteroids and surgery for your nasal polyps in CRSwNP.

TEZSPIRE is not used to treat sudden breathing problems. Tell your healthcare provider if your asthma does not get better or if it gets worse after you start treatment with TEZSPIRE.

Full Prescribing Information including Patient Information and Instructions for Use.

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